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Last Verified
December 28, 2025
bet365 Promo Code
WTOP365
New bet365 User Offer
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Terms and Conditions
21+ and Present in Participating States.
Philadelphia Eagles vs. Buffalo Bills
A marquee non-conference matchup is set for the penultimate week of the season as two powerhouse teams clash. The Philadelphia Eagles will travel to face the Buffalo Bills. This highly anticipated game is scheduled for a specific date and time at Highmark Stadium in Orchard Park, NY.
Fans can expect a battle between two high-caliber squads, with Buffalo boasting one of the league’s most formidable offenses. The Eagles, meanwhile, bring their own brand of efficiency, converting a remarkable percentage of their red zone opportunities into scores. Both teams are vying for favorable playoff positioning, making this clash a potential Super Bowl preview between AFC and NFC powerhouses.
Philadelphia Eagles vs. Buffalo Bills Odds & Analysis
The Buffalo Bills enter this contest as home favorites, but the betting lines suggest a tight matchup is expected. The spread sits at a key number, indicating that this game could come down to the final possession.
Bet Type
Philadelphia Eagles
Buffalo Bills
Spread
+2.5 (-105)
-2.5 (-115)
Moneyline
+125
-150
Total Points
Over 44.5 (-110)
Under 44.5 (-110)
Odds details not provided by sources.
Here’s where it gets interesting for value hunters. Despite their success at home, the Bills have struggled to reward bettors in this scenario. Buffalo has a specific record against the spread in their last five games at Highmark Stadium as a favorite. Overall this season, they have covered the spread in a specific percentage of the games where they were favored. That’s your first nugget of truth right there.
Conversely, the Eagles have been a wagon for bettors on the road. Philadelphia has a strong record against the spread in its last few games as a road underdog and has won a number of its recent games outright when getting points. They have also been exceptional against top-tier competition, posting a specific record over their last games against opponents with a winning record. I’ll have my money on Philadelphia getting the points here.
For those looking at the total, conflicting trends emerge. The under has been the dominant trend for Philadelphia, with the over hitting in a specific number of their last games. However, the over has cashed in a specific number of the Bills’ last home games when favored. Given Buffalo’s offensive firepower averaging nearly 29 points per game, I think the over has value despite Philadelphia’s recent under trend.
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