| Through the 2021 season |
|---|
Career save leaders since 1969, when saves became an official major league statistic (x-active):
| 1. Mariano Rivera | 652 |
| 2. Trevor Hoffman | 601 |
| 3. Lee Smith | 478 |
| 4. Framcisco Rodriguez | 437 |
| 5. John Franco | 424 |
| 6. Billy Wagner | 422 |
| 7. Dennis Eckersley | 390 |
| 8. Joe Nathan | 377 |
| 9. Jonathan Papelbon | 368 |
| 10. Jeff Reardon | 367 |
| 11. Troy Percival | 358 |
| 12. x-Craig Kimbrel | 355 |
| 13. Randy Myers | 347 |
| 14. Rollie Fingers | 341 |
| 15. John Wetteland | 330 |
| 16. Francisco Cordero | 329 |
| 17. Fernando Rodney | 327 |
| 18. Roberto Hernandez | 326 |
| 19. Houston Street | 324 |
| 20. Jose Mesa | 321 |
| 21. x-Kenley Jansen | 320 |
| 22. Todd Jones | 319 |
| 23. Rick Aguilera | 318 |
| 24. Robb Nen | 314 |
| 25. Tom Henke | 311 |
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