The driver who died at the scene is identified as Timothy Markin, 47, of Silver Spring, Maryland, according to Maryland State Police.
He was driving a Camry northbound on Maryland Route 5. Mark Latson, 57, of Hughesville, Maryland was driving southbound in the northbound lanes when the head-on occurred at 1:52 a.m. near Huckleberry Drive in Hughesville.
Latson was taken to Prince George’s Hospital for treatment.
All northbound lanes of Md. 5/Leonardtown Road were blocked for several hours before Bryantown Road/Olivers Shop Road.
Police are asking anyone who witnessed the crash to call 301-392-1231.
WTOP’s Ana Srikanth contributed to this report.