| Through April 2022 |
|---|
Career save leaders since 1969, when saves became an official major league statistic (x-active):
| 1. Mariano Rivera | 652 |
| 2. Trevor Hoffman | 601 |
| 3. Lee Smith | 478 |
| 4. Francisco Rodriguez | 437 |
| 5. John Franco | 424 |
| 6. Billy Wagner | 422 |
| 7. x-Craig Kimbrel | 394 |
| 8. Dennis Eckersley | 390 |
| 9. x-Kenley Jansen | 385 |
| 10. Joe Nathan | 377 |
| 11. Jonathan Papelbon | 368 |
| 12. Jeff Reardon | 367 |
| 13. Troy Percival | 358 |
| 14. Randy Myers | 347 |
| 15. Rollie Fingers | 341 |
| 16. John Wetteland | 330 |
| 17. Francisco Cordero | 329 |
| 18. Fernando Rodney | 327 |
| 19. Roberto Hernandez | 326 |
| 20. Houston Street | 324 |
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