TORONTO (AP) -- Sean Nolin left with some souvenirs, but not a whole lot of good memories, from his first taste of big league baseball.
Chris Davis hit his major league-leading 16th home run, Nick Markakis had three hits and three RBIs and the Baltimore Orioles beat Nolin and the Toronto Blue Jays 10-6 on Friday night.
Called up from Double-A to face the Orioles, Nolin (0-1) allowed six runs and seven hits in 1 1-3 innings. He suffered his first loss since Aug. 27, 2011, when he was pitching for Class A Lansing.
"Definitely not the way I envisioned it," a red-eyed Nolin said of his rough debut. "I think I just had too much energy going. I kind of felt like I already threw a few innings, kind of wasted some gas without doing anything."
Nolin was optioned back to the minors after the game, packing his bag and leaving with a copy of the lineup card, and a pep talk from manager John Gibbons.
"I told him 'I don't want you leaving here with any negative thoughts,'" Gibbons said. "'You'll be back. Someday you'll look back and laugh at this."
Maybe, but not tonight.
"It was a tough go for him, no question," Gibbons said. "(Catcher J.P.) Arencibia told me everything was kind of flat, flat in the zone."
The teams combined for 33 hits, 16 by Baltimore and 17 by Toronto.
"It was pinball out there tonight," Gibbons said.
Arencibia was the only starter on either side who didn't reach safely via a hit or walk. He went 0 for 5 with three strikeouts.
Toronto lost for the first time this season when scoring five runs or more, falling to 15-1 in those games. The Blue Jays set a dubious franchise record by allowing the first three batters of an inning to reach safely in three consecutive frames, doing so in the first, second and third.
J.J. Hardy, Danny Valencia and Adam Jones all went deep as the Orioles matched a season high in runs and set a season high with four home runs. Baltimore has hit an ML-best 66 homers this season.
"When we got a ball over the plate it seemed like we didn't miss it," Markakis said.
The Orioles have hit at least three homers in each of the past four games, their first such streak since a five-game run in August 1996. That year, the Orioles finished with eight double-digit home run hitters and set a baseball record with 257 homers.
Melky Cabrera, Brett Lawrie and Adam Lind all hit solo homers for the Blue Jays, but Lawrie and Gibbons were ejected at the end of the third.
Chris Tillman (4-2) allowed three runs and a season-high 10 hits in five innings to win for the fourth time in six starts. He walked none and matched a season high with seven strikeouts.
"The key was Tillman not walking anybody," Baltimore manager Buck Showalter said. "You've got to make them earn it."
The Orioles walked eight batters in Thursday's 12-6 loss.
Brian Matusz got two outs in the sixth, Tommy Hunter pitched 2 1-3 innings and Darren O'Day finished in the ninth.
Nolin, 23, put his team in a hole before recording his first out. After singles by Markakis and Manny Machado, Hardy hit a three-run drive to left, his ninth.
Cabrera got one run back with his first career leadoff homer and second of the season in the bottom half, but the Orioles chased Nolin with three more in the third. A double, a walk and a single loaded the bases for Markakis, who cleared them with a double.
Lawrie led off the bottom of the second with his fifth home run and Colby Rasmus doubled and scored on Emilio Bonifacio's single, but the Orioles added to their lead in the fourth against Ramon Ortiz.
Davis led off with a second deck homer, his third in three games and fourth in five. Two batters later, Valencia hit his first homer, a two-run drive.
Jones made it 10-3 with a leadoff homer off Brad Lincoln in the sixth, but the Blue Jays scored twice against Matusz in the bottom half. Munenori Kawasaki hit an RBI double and scored on Cabrera's single.
Lind cut it to 10-6 with an opposite field homer off Hunter in the seventh, his fourth.
Lawrie was ejected by home plate umpire Dan Bellino after he was called out looking to strand runners at the corners in the third. Lawrie flipped his bat and tossed his helmet and gloves on the ground as he walked up the third base line toward his position, leading to his first ejection this season.