TORONTO (AP) -- Paul Konerko didn't have much fun facing old friend Mark Buehrle, and not just because his former teammate struck him out in a key situation.
Buehrle pitched in and out of trouble into the seventh inning, J.P. Arencibia and Maicer Izturis hit solo homers and the Toronto Blue Jays topped the Chicago White Sox 4-3 on Monday night.
Buehrle ended the fifth by fanning Konerko on a curveball to strand runners at the corners.
"I didn't have much fun with it, and I don't think he did, either," Konerko said. "But it was a good game, and he pitched well."
Buehrle (1-0) went 6 1-3 innings in his first career start against the White Sox, allowing two runs and nine hits. The left-hander walked two and struck out three. Both runs he allowed came in the first.
"Once he got through that first inning it kind of became a clinic on hitting spots, changing speeds," White Sox manager Robin Ventura said. "You've seen this his whole career. He's just a smart pitcher."
A four-time All-Star during his 12 seasons with the White Sox from 2000-11, Buehrle starred for Chicago's 2005 World Series championship team, pitched a no-hitter in 2007 and perfect game in 2009.
"He had a tremendous career there," Blue Jays manager John Gibbons said. "He helped, in a lot of ways, make the White Sox what they are. All those years when they were playing really well, he was one of the key guys."
Buehrle signed with Miami before the 2012 season but spent just one season in South Florida before he was sent to Toronto in a 12-player trade last November.
He found it "a little crazy" facing the White Sox for the first time.
"It was different seeing the Sox uniform in the batter's box," Buehrle said. "Usually it's behind me. It's weird rooting against those guys. I've rooted for them for 13 years and wanted them to win every game. This is the first game in I don't know how long that I'm actually rooting against them."
Facing a lineup full of old friends forced Buehrle to be more focused than usual.
"I tried not to take a look at too many guys stepping into the batter's box because I knew I'd start laughing or something bad would happen," he said. "I just tried to focus on the glove, which is not me. Usually I'm out looking around and having fun."
Buehrle acknowledged changing up some pitch patterns to keep the White Sox guessing.
"It seemed like everything was working," he said. "J.P. called a great game and we had a good game plan going in. Obviously, knowing that they know me, we kind of changed a few things up."
Arencibia went deep in the first and Izturis connected to begin the second as the Blue Jays opened a seven-game homestand with their third victory in four games.
Esmil Rogers pitched one hitless inning of relief before the White Sox rallied in the eighth against Aaron Loup. Adam Dunn was hit by a pitch, went to third on Dayan Viciedo's double and scored on a sacrifice fly by Alexei Ramirez. Loup struck out Tyler Flowers to preserve the one-run lead.
Casey Janssen finished for his fourth save in as many chances.
Right-hander Gavin Floyd (0-3) remained winless as the slumping White Sox lost for the sixth time in seven games.
Chicago jumped on Buehrle with two runs in the first as Konerko and Viciedo hit RBI singles.
Toronto quickly tied it in the bottom half when Emilio Bonifacio led off with a double, advanced on a passed ball and scored on Melky Cabrera's sacrifice fly. Arencibia followed with a homer that bounced off the top of the wall in right center, his fourth.
Izturis made it 3-2 with a leadoff drive to right in the bottom of the second, his second, and the Blue Jays tacked on one more in the fourth when Munenori Kawasaki hit his first career triple and scored on Bonifacio's sacrifice fly.
The White Sox put runners at first and third with two out in the fifth but Buehrle escaped by fanning Konerko.
"Big situation right there and I just knew I had to make a pitch," Buehrle said. "I know how great a hitter (Konerko) is."
Toronto chased Floyd in the bottom of the fifth, loading the bases with one out on a single and a pair of walks. Hector Santiago came on and got Izturis to ground into an inning-ending double play.