AP Pro Football Writer
The Detroit Lions knew nothing about success in Washington. Through 21 trips to the nation's capital, they owned an 0-fer.
The Lions (2-1) ended a 21-game road losing streak against the Redskins, the second longest in NFL history. Detroit's last win away from home in the series came in 1935 against the Boston Redskins, two years before the franchise's move to Washington.
This one came as Matthew Stafford completed 25 of 42 passes for 385 yards with two touchdowns in a 27-20 triumph. Calvin Johnson and Nate Burleson both had 100 yards receiving for Detroit.
"You never know how the cookie's going to crumble, and it feels good that it crumbled our way this time," Detroit cornerback Rashean Mathis said. "I wasn't a part of the past, but I am part of the future, so it feels good to give the fans something to feel good about, and we can demolish a record, our streak, that was going on for years and years and years."
Another losing string was snapped by the Titans. Tennessee had fallen nine straight times to San Diego before Jake Locker connected with rookie Justin Hunter on a 34-yard touchdown pass with 15 seconds left for a 20-17 win.
The last time the Titans beat the Chargers was 1992 when the team was still in Houston.
"We needed a win like this," said Tennessee coach Mike Munchak, who was with the franchise when it was the Oilers and last beat San Diego.
Also Sunday, it was Indianapolis 27, San Francisco 7; Seattle 45, Jacksonville 27; Miami 27, Atlanta 23; Cincinnati 34, Green Bay 30; Baltimore 30, Houston 9; New Orleans 31, Arizona 7; Cleveland 31, Minnesota 27; New England 23, Tampa Bay 3; Chicago 40, Pittsburgh 23; Carolina 38, the New York Giants 0; Dallas 31, St. Louis 7; and the New York Jets 27, Buffalo 20.
On Monday night, Denver (2-0) hosts Oakland (1-1).
Week 3 began when Kansas City defeated Philadelphia 26-16 on Thursday night.
Lions 27, Redskins 20
Robert Griffin III and the defending NFC East champion Redskins fell to 0-3. Griffin completed 32 of 50 passes for 326 yards and had his fourth interception of the season, one shy of his 2012 total. The Redskins scored an offensive touchdown for the first time this season.
But they couldn't do what every previous Washington team had done against Detroit.
"The food isn't going to taste that good tonight," said cornerback DeAngelo Hall, who had a 17-yard TD on an interception. "Still trying to wrap my head around what we can do to get better."
Titans 20, Chargers 17
At Nashville, Locker ended the slide by completing seven passes to six receivers for 94 yards on the winning drive. He finished with 299 yards passing and ran for 68 yards. The Titans (2-1) outgained San Diego 452-277 yards, with Nate Washington catching eight passes for 131 yards. Chris Johnson ran 19 times for 90 yards.
San Diego (1-2) led most of the game despite having four starters out because of injuries and losing a fifth to an injured foot in the first half.
Colts 27, 49ers 7
At San Francisco, Andrew Luck beat college coach Jim Harbaugh. Trent Richardson scored a 1-yard touchdown on his first carry in his Colts debut after being acquired on Wednesday from the Browns. He was drafted two spots behind Luck at No. 3 last year.
Ahmad Bradshaw added a 1-yard TD run in the final minutes, and Adam Vinatieri kicked two field goals for Indianapolis (2-1).
It was Colin Kaepernick's first home loss at Candlestick Park as a starter. San Francisco (1-2) struggled to establish a passing game with tight end Vernon Davis sidelined by a hamstring injury.
Linebacker Aldon Smith will miss Thursday night's game at St. Louis and perhaps sit out longer, according to 49ers CEO Jed York. Smith, who played Sunday, will seek treatment following his arrest Friday for suspicion of driving under the influence and marijuana possession. After the loss, Smith apologized and acknowledged he will get help, but didn't field questions.
Seahawks 45, Jaguars 17
At Seattle, Russell Wilson matched his career high with four touchdown passes, two each to Sidney Rice and Zach Miller. The Seahawks improved to 3-0 for the first time since 2006, beginning a stretch of four straight games against the AFC South. Seattle came in as a 19-point favorite and never gave Jacksonville (0-3) a chance.
The Seahawks forced Jacksonville into three turnovers. They sacked Chad Henne four times, and Maurice Jones-Drew, playing with an injured ankle, was limited to 43 yards on 19 carries.